FlowChamber

FlowChamber develops a test that delivers the coagulation status overview of whole blood samples under conditions of (patho)physiological shear rates present in the circulation. The Hemostatic Flow Analyzer is based on flow perfusion chamber technology and yields

information about platelet adhesion, activation, thrombus formation and coagulation. With the input of multiple agonists and several output parameters, using a small blood sample of 500 µL, high output can be generated within a small timeframe. Flowchamber offers a rapid test in which the coagulation status of the blood of a patient can be determined to come to a faster diagnosis and bleeding management for the patient. Maastricht Instruments and UM-IDEE supported the development and product incubation of the flowchamber technology together with Maastricht University experts.

https://www.flowchamber.com/

FlowChamber is developing the Hemostatic Flow Analyzer that consists of the FlowChamber, an imaging system, software and accessories.

FlowChamber

Whole blood flows through the disposable FlowChamber and interacts with specific agonists that depends on the presence of specific receptors in the thrombus formation process. The following hemostatic parameters can be determined simultaneously:

  • Platelet aggregation, adhesion and interaction
  • Thrombus size
  • Granule secretion
  • Fibrinogen binding
  • Clotting time
  • Maximum lysis

In the near future many other parameters can also be measured. Important to share is that all data are available within 20 minutes at 37 degrees Celsius and adjustable shear rates (1000 or 1600 s-1). A full list of hemostatic parameters that are available can be found here.

Microscopy imaging system

The interaction between the blood and the agonists is monitored by a microscopy imaging system. The system we are developing will be temperature-controlled, adapts the room temperature stored FlowChamber and is a closed easy-to-use system with full automation. In 2020 this system will be on the market for clinical use.

Software

Images obtained by the microscopy imaging system are analyzed and yield quantitative and qualitative vales of the hemostatic parameters. The software is fully automated and very user-friendly.

Accessories

The interaction between the blood and the agonists is monitored by a microscopy imaging system. The system we are developing will be temperature-controlled, adapts the room temperature stored FlowChamber and is a closed easy-to-use system with full automation. In 2020 this system will be on the market for clinical use.

Freek Boesten
Business development
freek.boesten@maastrichtinstruments.com
+31654328206